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Grants.govALN 93.473PAR-27-045

HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)

National Institutes of Health

Amount not specifiedCloses in 31 days· Oct 30, 2026

Summary

The NIH Helping to End Addiction Long-term ® (HEAL) Initiative is releasing this Notice of Funding Opportunity (NOFO) to support a phased mechanistic clinical research program focusing on understudied biological mechanisms that drive joint pain. The phased projects supported by this program (of up to five years total in duration) will first identify and validate multi-tissue mechanisms underlying joint pain, then test non-pharmacologic or multimodal interventions that directly target these mechanisms. The initiative responds to priorities identified in the 2023 HEAL Whole Joint Pain Workshop and supports the broader goals of the NIH HEAL Initiative and the Make America Healthy Again vision by advancing safe, non-addictive, and prevention-oriented approaches to chronic pain.

Related documents

Geography
US
Award range
Amount not specified
Cost share
Not required
Open date
Sep 28, 2026
Close date
Oct 30, 2026
Funding type
Grant
Opportunity type
Discretionary
Source
Grants.gov

Eligibility

NonprofitFor-profitGovernmentInstitution

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. | applicant types: For profit organizations other than small businesses; County governments; Small businesses; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of higher education; Special district governments; Native American tribal organizations (other than Federally recognized tribal governments); Independent school districts; Native American tribal governments (Federally recognized); Public housing authorities/Indian housing authorities; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; City or township governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); State governments; Public and State controlled institutions of higher education

Categories

Economic DevelopmentEducationHealthInfrastructureHousing

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